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Best CBD Oil For Pets

May 17th, 2022 by Cara Oorbeck

Best CBD for Pets 2022Best CBD Oil For Pets

I have been working for Green Wellness for the past four years and I have had the privilege of getting to know many of you and your stories. I have heard about how CBD has given you a better quality of life, assisted you with pain, or helped many of you with your anxiety and mood. Many of these stories have included how CBD has benefited your pets. I have heard of CBD benefitting pets with everything from CBD for dog arthritis, pet seizures, pet anxiety, to pet issues pets like hot spots, allergies. I love hearing the success stories and I personally have seen first hand how my four dogs and three cats have benefited from the use of daily CBD oil for pets. 

What Is CBD?

First let’s talk about what CBD hemp oil for pets is and why it can be helpful to your pets. You see, all mammals share the same Endocannabinoid System (ECS.) That means that all of your family members – including the furry ones – can see benefits from cannabinoids like CBD. So what is CBD? CBD is one of over 100 compounds found in either the hemp or the marijuana plants. These compounds are actually called cannabinoids. In the hemp plant, CBD makes up more than 40 % of the cannabinoids. Because CBD is non psychoactive it makes it a great option for our pets health and well being.

CBD and many of the other cannabinoids that benefit our pets bodies act as a neutralizer or as a stabilizer for the body, assisting a human or pet’s body in returning to a neutral state or a state of homeostasis. This is why many people believe that CBD can be used to benefit a pet with pain and inflammation issues as well as anxiety, stress, seizures, fireworks and more. It is important to note that all CBD is not the same and finding the right CBD for your pets can be tricky. Let’s take a look at the different types of CBD. There are three main ways CBD is processed: 

  •  Full Spectrum CBD for pets which consists of the whole plant and all the plants compounds or cannabinoids are present.
  •  Broad spectrum CBD for pets which consists of the part of the plants compounds or cannabinoids while other compounds, cannabinoids and terpenes can be removed. Usually the cannabinoid that is mostly removed is THC..
  • Isolate CBD for pets which means everything from the plant has been removed and only the cannabinoid or compound CBD are present.

In all cases, it’s important to only give your pet lab tested products.  You need to know that your CBD is free of contaminants. Additionally, you want confidence in the amount that you’re giving your furry family member and you need to know that what you think is in that bottle is actually there.  Rest assured that everything GWL carries is lab tested.  If you want to learn more about that, take a look at our recent article on unraveling lab reports.

How do I give my pet CBD oil?

We always recommend starting with a small serving for pets and people. Begin with 1-2mg per 10lbs of pet body weight for the first 5-7 days. If enough benefit is not seen, we recommend doubling that serving for week two. Those gradual increases can continue, giving your pet’s body several days to adjust each time. Our goal is for them to see benefits within 2 to 3 weeks. While we know that our pets can’t talk, we can usually tell how they are feeling by their actions. If you are not seeing that these products are helping them, please reach out by email at support@greenwellnesslife.com or by phone toll free at 888-772-7875! We are here to help you and your pets on this journey.

Pet CBD Side Effects

One of the benefits of using CBD verses other pharmaceutical products prescribed by your pets veterinarian is the minimal side effects. CBD can cause some drowsiness or upset stomach if given without food. There is one more important concern that should be mentioned. The American Kennel Club described it as “The main concern with CBD is that it inhibits a chemical in the body called cytochrome P450 that is responsible for metabolizing most drugs. If a drug’s efficacy depends on its metabolized product, CBD could render it less effective. If a drug’s safety depends on it being cleared from the body within a certain time frame, CBD could cause it to build up to toxic levels. Never give your dog CBD without your veterinarian’s knowledge if your dog is taking other drugs.”

What are some of the best CBD oils for dogs and cats?

Part of my job is researching and trying CBD to bring into our store. That also means my family, including my pets try a lot of CBD. Here are a few of our favorites in our household. My fur babies definitely have some they love more than others! I have also included pictures so that you can meet the GWL taste testers.

1. Most Cost-Effective Pet CBD

The most cost effective CBD for pets is usually in a tincture format. Hemplucid Pets CBD Tincture with 300 mg per bottle is (formerly Roxy Pets CBD by Hemplucid) a formulated full-spectrum CBD tinctures that can be used with cats or dogs. Available in two great flavors including fish flavored CBD tincture and chicken CBD pet tincture your cats and dogs are sure to love it. Yum!

This is a delicious, nutritious addition to your cat or dog’s daily diet. It’s also the only fish oil based CBD product that we are aware of on the market today! I give this tincture to my feline babies shown above. I just add a little to Sophie, Bella and Miss Kitties food and we see a difference in joint mobility for our older cat Miss Kitty and calming for our busy cats that are sisters. With 300 mg per 30 ml/1 fl oz each, it is a great option for smaller pets or pets who do not need to take as much. Each dropperful has 10 mg.

2. Our favorite CBD for an older dog

Holistapet CBD Dog Treats are a favorite in our house. Lucy pictured above is our 16 year old schnauzer. That is right, 16!!! She takes her CBD daily and she is an incredibly active 16 year old dog (that is 112 years old in dog years!!). She is still playful and happy. She can even jump up on our couch, we truly see the difference when we do not give her Holistapet CBD Joint and Mobility dog treats. These treats are not only for joint mobility, with three different options to choose from they are definitely a fan favorite at our house! I have listed the three different options below and I am not the only one that loves these treats for dogs. They are also a leading brand in the CBD pet market.

  • Blueberry & sweet potato (Heart and Immune Care) – Formulated with blueberries, flaxseed and sweet potatoes to boost your pets immunity, strengthen cardiovascular health and promote healthy skin and coat.
  • Green apple & peanut butter (Stress Relief) – Enhanced with hemp, chamomile and L-theanine to help your dog maintain a calm energy and relaxed state of mind.
  • Pumpkin spice & cinnamon (Joint and Mobility Care) – Formulated with turmeric root and boswellia to increase strength in joints and reduce physical discomfort.

3. Our favorite CBD for larger pets

CBDfx CBD Pet Tincture is a must have in our house with a Great Dane. Due to Molly’s big size, (she is our big princess) weighing in at 140 pounds and measuring 6 foot 2 inches tall, she is not able to use just any CBD. The CBDfx CBD Broad Spectrum Pet Tincture increases the milligrams of the CBD boasting a whopping 1000 mg of CBD per 1 fl oz. The CBDfx Pet Tincture is uniquely formulated to be a great fit for your larger pets while giving you a 0 THC option, made from hemp. The tincture is a yummy bacon flavor that your fur baby is sure to love, just like our big girl Molly. This CBD pet oil is a great option for those larger pets who need a little more CBD. We give Molly 12-15 drops in her food once a day and we notice a difference in her joint pain and every day movement. Only the best for our princess!

4. Our favorite CBD for anxious Dogs

Martha Stewart Treats

In our house we are a sucker for a hurting animal. Rizzo, our little mutt, came to us from a very abusive and bad situation. We have had him for four years now and he is the most loving, quirky dog I have ever owned. He is also incredibly anxious. We have worked with him in helping him deal with his anxiety and to help him in feeling safe, but without his CBD he is a bundle of nerves. The difference we see in Rizzo when he takes his CBD and when he doesn’t is remarkable. He loves the Martha Stewart CBD dog chews. They smell delightful and are, in true Martha fashion, gourmet!

These CBD Soft Baked Calm Chews are available in a great tasting chicken and cranberry flavor and two different strengths. These treats combine quality CBD from Broad Spectrum hemp extract and chamomile for a calm, balanced pup.

  • Small to Medium: 5 to 35 pounds with 9mg CBD and 150 mg Chamomile per chew
  • Large: 36 to 110 pounds with 26 mg of CBD and 250 mg of Chamomile per chew

Rizzo gets one Calm chew daily and on some days when we have something going on or he gets real nervous, we also may put some of the Hemplucid CBD pet tincture in his food. This has been an incredible help to us with Rizzo.

5. Our Favorite CBD for Picky Pets

Koi Dog Treats

Molly is not only big but she is also our picky pet. Molly will not eat any of the other CBD treats. I cannot get her to even try some of the other treats, but the Koi CBD Soft Chew pet treats are by far Molly’s favorite! She simply inhales these treats! The only downfall to these treats is the cost. For bigger dogs they can get pretty expensive. Molly has to take 3 to 4 treats to get her daily serving size so it is not an option I use daily for Molly, but we do give her a treat every know and then! Each CBD Koi pet treats are 2mg per treat and even my cats love these treats. If you cannot get your pet to take CBD this is a possible option that may help.

incredible help to us with Rizzo.

6. Our Favorite CBD treat for Kitties or small dogs!

Treatibles CBD Cat Chews

Treatibles CBD Cat Soft Chews are delicious, soft, chewable and full of natural phytocannabinoids that is made just for cats. That’s right – no more dog treats for our kitties! We have searched far and wide to find soft treats that your furry feline will beg for and these get two paws up. Treatibles is another one of the leading CBD pet brands on the market and you can be rest assured your kitty is getting a quality treat with the best ingredients in their CBD treat. With 150 mg We think your kitty will love them, but we know that cats can be more finicky than their canine counterparts, so don’t worry you can try them out my miss kitty loves her treats but if your fur baby doesn’t we do have other options and a 30 day money back guarantee.

The GWL Favorites are only a small selection! Give us a call or email us for more info or other available CBD Pet products. 

GWL Pet Products

The products shown above are only a small selection. We have a variety of pet products beyond the products listed above and every one of them has been tried by each of our pet testers. If you do not feel any of these products will work for your pet, feel free to give us a call or email us and we will be happy to assist you in finding the right CBD pet product for your furry friends!

Does CBD Work for Dogs? – American Kennel Club (akc.org)

Frontiers | Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs | Veterinary Science (frontiersin.org)

CBD for Pets: What to Know About Benefits, Safety, and More – GoodRx

CBD 101 | A Beginner’s Guide To CBD | What You Need To Know (greenwellnesslife.com)

 


CBD 101 A Beginner’s Guide To CBD

March 12th, 2022 by Lashonda Broom

 

CBD 101 BlogCo-authors  Lashonda Broom & Cara Oorbeck(GWL Staff )

 Lashonda Broom, RN & HHP                       Cara Oorbeck, GWL Staff
Cannabis Nurse Medical Reviewer,

Cannabinoids, or compounds found in hemp and marijuana plants, are definitely a popular topic these days.  So what’s all the fuss about? What are these compounds and how do they work? How do I take them and how much do I take? And most importantly, what will it help me with? 

Whew, that’s a lot of questions. Let’s start with our bodies and the system that these compounds interact with. It is often assumed that the benefits derived from CBD and other cannabinoids are a result of introducing some substance not already found in the body to your system. This couldn’t be farther from the truth. Let’s talk it through. 

What is CBD?

Before diving into how cannabinoids interact with the body, it’s first important to have an understanding of what CBD is. CBD is a natural essential oil that is rich in nutrients and one of over 100 different cannabinoids found in cannabis plants. Scientists are still researching cannabinoids and there may be more we haven’t yet identified. 

CBD can be found in all of the different types of cannabis plants, but it is more prominent in hemp plants where it makes up about 40% of the cannabinoids extracted from the plant. CBD is not psychoactive like THC, so it will not produce any kind of high. 

What is the ECS…Endocannabinoid System?

The Endocannabinoid System or “ECS,” is a system that provides the body with many similar cannabinoids to those of hemp oil. Cannabinoids are complex chemical compounds that act on receptors in cells. The hemp plant produces over 100 different cannabinoids (or phytocannabinoids); the human body (as well as other mammals) also naturally produces cannabinoids (or endocannabinoids). This means that your body already uses cannabinoids for many of its functions, such as regulating mood, appetite, pain-sensation, and memory. These cannabinoids promote homeostasis (balance) at every level of biological life. 

What do Cannabinoids do?

The function of cannabinoids in your body (regardless of whether they are naturally produced by your body or from a plant) is to act as receptors for cells. What these receptors do is act as conduits for messages from the brain to the cells. They are the “bridge” that enables your body to operate as it should. Because of this, they are essential for a healthy body, which includes memory, appetite, and mood.

While your body uses the endocannabinoids produced internally, it also reacts to phytocannabinoids from sources like cannabis and hemp. This is where CBD and other plant-based cannabinoid oils come in.

Endocannabinoid Receptors CB1 and CB2

The ECS is composed of two primary endocannabinoid receptors: CB1 (found predominantly in the brain, nervous system, and outlying organs and tissues) and CB2 (found predominantly in white blood cells, tonsils and spleen). Although CBD has low affinity for either of these receptors, it does interact with other nominal receptors with remarkable effects. For example, CBD activates the receptor GPR55, which has been shown to assist in treating pain and inflammation. CBD has also been shown as a partial agonist (which is a term referring to something that attaches to a cell receptor and causes an action to occur in that cell) to the 5-HT1A receptor, which may lead to cannabidiol’s anti-depressant, anti-anxiety, and neuro-protective effects.

Why take daily CBD?

Because the ECS is involved in the body’s communication with its cells and their functions (including repairs), cannabinoids are crucial for the body’s constant repair of cells and their functions – maintaining that balance. When more cannabinoids are introduced to this delicate system, they can stimulate the cells into functioning as the brain directs them to, and can facilitate healing where the body’s own ECS has failed. In this, it is clear that when the ECS is failing to do its job, phytocannabinoids from CBD oils can “pick up the slack” and act as receptors for cells that were malfunctioning due to a lack of endocannabinoids. This makes CBD crucial for maintaining (or, in many cases, restoring) a healthy balance of receptors in the body.

Isolate, Full Spectrum or Raw?

Finding the right CBD for your needs and body can be confusing. We answer customer questions all day long and we have found that there is no one size fits all. Each individual is different. One criteria that is important for everyone is quality. It’s important to make sure that you’re taking a product free of harmful contaminants. Additionally, you want to make sure that what you think is actually in that bottle is really there. You can only do that through a lab test.  Your takeaway for CBD 101 is to make sure that you’re taking a lab tested product. If you want to learn more about that, take a look at our article on unraveling lab reports.

Next up, let’s take a look at the different forms of CBD: What is the difference between them? Who would use which version, and why?

Is CBD all that I want from the plant?

First of all, it’s important to understand that cannabidiol (CBD) is only one of the major compounds that are present in the cannabis plant – both hemp and marijuana. It happens to be one of the most studied compounds by scientists because of its powerful potential and the fact that it occurs in greater quantities in the plant than some of the other more than 80+ compounds. As evidence of its interest to scientists and researchers, CBD has been used in multiple pharmaceutical solutions. One of the most recent to be approved by the FDA is Epidiolex, a CBD-based drug used to treat childhood epilepsy.

Full Spectrum CBD Oil: A Rainbow of Compounds

Despite its fame, CBD is not the only major compound found in cannabis sativa. There are a range of other compounds that make up the plant. When we are talking about all of those compounds together, we use the term “full spectrum.” This is just another way to say “whole plant”. A full spectrum CBD oil means that manufacturers use the whole plant and all the cannabinoids that are naturally occurring as active ingredients in your product. 

Full-spectrum is unique in that it can introduce the user to the possible positive effects of the other components of cannabis working together, often referred to as the “entourage effect”. Though there are many different cannabinoids in the plant, here are a few of the better-known ones included in full spectrum products.

  • THC (Tetrahydrocannabinol) – Full-spectrum CBD from the hemp plant does include trace amounts of THC, which is well-known as the psychoactive element of cannabis – or the part that makes you high. That THC level can’t be more a .3% concentration when coming from a hemp plant, so it has no psychoactive effect. There is technology that is isolating the THC out of some full spectrum products making it what is now being referred to as a “broad spectrum.” This means that it started as a full spectrum (whole plant) product, but the THC was isolated and removed. These products will usually specify 0 THC.
  •  CBN (Cannabinol) – This component of cannabis does not occur in as great a quantity, so we don’t know quite enough about it yet. What science is finding is exciting, though. Some early studies are showing that there may be real benefits for people struggling with sleep issues.
  • CBG (Cannabigerol) – Interestingly, CBG has been shown to stimulate growth of new brain cells and bone growth. These unusual properties make it a fascinating compound for researchers to study.
  • THCV (Tetrahydrocannabivarin) – THCV has a similar molecular structure to THC and is also psychoactive. Research is finding that it’s very similar to CBD as well, in working to balance and neutralize cells.

All of these compounds, and many more, interact in a full-spectrum product. Who would this form of CBD work for? A full-spectrum CBD oil would work great for someone who wants to work with all the elements of the cannabis plant for a holistic approach. It would be very useful for those who are interested in other compounds, like CBG and THCV, and their effects. We have often seen excellent results for people living with inflammatory pain. 

It’s important to keep in mind that unless clearly stated to be a 0% THC product, full spectrum products will likely contain a trace amount of THC. That legal limit, if coming from hemp, is 0.3%.  While it’s not likely that quantity would cause you to fail a THC drug test, it is possible. 

CBD Isolate

In a product made with a CBD Isolate, only one cannabis compound is present – CBD. It’s been individually extracted from the plant without any of the other cannabinoids, terpenes, or plant matter. Some might say that the isolate is missing some of the other compounds that make full-spectrum oil special. While this is true to an extent, there are plenty of reasons why someone might want just the CBD oil.

For one, maybe they’re only interested in specific CBD oil impact. If a customer has discovered that CBD works best alone to treat their particular disorder or ease their symptoms, then they would definitely want to stick with what works. Other people might feel uncomfortable with even trace amounts of THC. In this case, an isolate CBD is a perfect solution. 

Others may actually be allergic or have had bad reactions to other cannabinoids or plant matter. In this case, a CBD isolate would be the best choice.  Additionally, we have seen excellent results with isolate CBD for people looking for help with mood stabilization.  The other cannabinoids and plant matter aren’t usually as necessary to see a benefit there. 

Raw CBDA-CBD

Cannabidiolic acid (CBDA) is a chemical compound found in the resin glands (trichomes) of raw cannabis plants.” In this case, raw means unheated and uncured. Many of the conditions that respond with CBD also respond well to CBDA. There is a growing body of information that is talking about the benefits of raw or CBDA having a greater effect on people living with chronic pain. There is also a patent pending by GW Pharmaceuticals using CBDA in conjunction with CBD for anxiety and psychotic disorders.

Product Options

Now that you understand the way that the ECS works and the different processing types of products that come from cannabis plants, let’s talk about products. In short, CBD and it’s fellow compounds can come in pretty much any package type that you’re interested in – from chocolate to bath bombs to hemp flower. 

Pricing will vary but will be based on total milligrams of active ingredients per container.  When you see a 300mg lotion, that means that there are 300mg of cannabinoids in that whole bottle – not in each amount that you put on your skin.  You’ll see the same thing on a tincture, bottle of gummies, etc.  Those package sizes can vary as well.  Some are much more concentrated than others, so you may have the same amount of cannabinoids (your active ingredient) and a similar price point in a tiny 10ml bottle and a large 2oz bottle.  When you’re product shopping, you will want to look at that total strength per package as well as how much you’re going to take every day. 

We break it down into three main product categories – let’s talk them through: 

1) Topicals

These cover anything that you’re applying to your skin.  

  • Benefits in 15-30 minutes.  
  • The downside is that it won’t last as long – usually 4-6 hours.  
  • Topicals are a great fit when you’re dealing with a skin issue or are looking for inflammation relief at that site.  
  • Topicals won’t generally get into your bloodstream (with the exception of some CBD patch molecules that are small enough to do so).  
  • Intended to provide relief to the muscle, joint, and skin tissue.  
  • You can definitely use a topical along with a booster and a daily supplement. 
  • Use them where it hurts – when it hurts. Consistency isn’t key here.  

2) Boosters

Boosters avoid the digestive system to get to work quickly. 

  • Benefits in 15-30 minutes.
  • Like a topical, they get to work and then dissipate within 4-6 hours.  
  • Absorbed through your cheek or taken in through your lungs.  
  • The intent is to provide a bit of extra CBD on a day when you need it.
  • Use them as needed – consistency isn’t critical.  
  • As they are quick to leave your system, we wouldn’t recommend a booster as your only source of CBD and other cannabinoids. 

3) Daily Supplements

If you’re only going to take one type of cannabinoid, we would ask that you make it a daily supplement.  You’ll ingest these – and they come in all kinds of forms: 

Raw Oil

This is the plant extract in its most natural form – it’s likely been filtered 1 or more times and will taste grassy and earthy. Your serving size will be measured in paste quantity. We use the term “grains of rice.” Raw Oils will always be Full Spectrum. 

  • Pros: No additives, Flexible Serving Size
  • Cons: Difficult to Measure/Take, Earthy Flavor

Tincture

This is a liquid that you place under your tongue. It starts with the raw oil, but has a carrier oil and possibly flavoring added to it. Serving size will be measured in drops or dropperfulls. Tinctures can be Full Spectrum, Broad Spectrum or Isolated CBD. 

  • Pros: Flexible Serving Size, Added Flavoring, Quick Sublingual Absorption 
  • Cons: Can be Difficult to keep Serving Size Consistent

Capsules/Softgels

Capsules and Softgels are encapsulated tincture.  Serving size will be measured in capsules. 

  • Pros: Consistent Serving Size
  • Cons: Lack of Flexibility in Serving Size

Edibles (Gummies, Candies or Chocolate)

These options take a raw oil or an isolated CBD powder and add it into a gummy, candy or chocolate recipe. Raw Oils taste earthy, so full spectrum edibles are harder to come by than more filtered options. Serving size would be measured per piece. 

  • Pros: Easy to take
  • Cons: Lack of Flexibility in Serving Size, Priciest Option

How Much Do I Take?

Our goal is always to see the best possible results with a minimal amount of stuff in your system.  We talk in terms of serving size rather than “dose” because CBD is considered a food supplement – not a drug. In our experience, most people see benefit between 15-50mg daily.  We do have customers that do well with 5mg daily, and others who need 100mg, but 15-50mg taken consistently is the standard. 

We know that when you’re hurting, it’s always tempting to take a high serving to feel better.  We encourage you to step away from that and start small.  Some people do very well with a small amount of CBD to get their body back into neutral. We all want to be that person! Start there and work up if you need to. CBD supplements are intended to work over time – not instantly.  Don’t jump your serving up on a bad day – that’s what boosters are for.  If you’re not consistent in your serving size, you may not see the benefits that you are hoping for.

Getting Started

If you’re new to CBD, here’s how we recommend getting started: 

  • Day 1-5: Start with 10-15mg daily
    • Be consistent with the time of day that you take it. Raw CBD can be energizing, so we recommend morning. 
    • Any supplements that are sleep aids should be taken 30-60 minutes before bed. 
    • We always encourage you to take CBD on a full stomach.
  • Day 6-10: If you aren’t seeing the benefits you’re looking for, double your daily serving to 20-30 mg. 
    • Stay consistent
  • Day 11+: As long as you are seeing some benefit, stay the course. 
    • You can continue to increase your serving as needed, giving your body a couple days to adjust
    • You’ve got cannabinoids in your system, so your adjustment time will be quicker
    • If you’re not sure if you are seeing benefits, stop taking it for 3-5 days. That’s enough time for you to see if there was a difference for your system. 

We love starting with a tincture (liquid) because that serving size is so flexible, but if you’re more comfortable with a gummy or a softgel, go with that! The best CBD for you is the one that you will take every day. I’ll say it again: The best CBD for you is the one that you will take every day

No One Size Fits All

Whatever your choice when it comes to CBD, it’s important to make sure you’re aware of your options, in both product type and serving size. What your body needs may change. Every system is unique. We know it’s hard to hear, but there truly is no one size fits all. At the end of the day, the best CBD for you is the one that you are most comfortable with and see the greatest benefit from. 

Sources 

 


What Are CBGA, and CBDA?

January 12th, 2022 by Cara Oorbeck

There is a study that was released recently by Oregon State University that discusses promising findings about the potential effects of CBDA & CBGA in blocking the cellular entry of sars-CoV-2 and other emerging variants.  According to the university, “Van Breemen and collaborators, including scientists at Oregon Health & Science University, found that a pair of cannabinoid acids bind to the SARS-CoV-2 spike protein, blocking a critical step in the process the virus uses to infect people.

The compounds are cannabigerolic acid, or CBGA, and cannabidiolic acid, CBDA, and the spike protein is the same drug target used in COVID-19 vaccines and antibody therapy. A drug target is any molecule critical to the process a disease follows, meaning its disruption can thwart infection or disease progression.

We at Green Wellness, want to make sure you know that these are currently just studies and much more research needs to take place before this can be said conclusively!  However we thought you may want to know a bit more about some of the minor raw cannabinoids and what products you can find these compounds in.  Not all CBD products have CBDA and CBGA in them.  Keep reading to learn more!

New acronyms?

While we typically associate cannabis with two cannabinoids (THC and CBD), there are dozens upon dozens of other, rarer, cannabinoids contained within each plant. So why don’t we hear more about these other chemical compounds? Their rarity. Most cannabis plants will contain only around 1% in mass of all the minor cannabinoids. In fact, this is why you don’t see isolates sold of CBN, CBDA, and CBG; they are too costly to isolate and sell at profit. 

But, despite their low concentrations in cannabis, they do have potential benefits to bodily wellness and their positive effects can be understood with a little reading and curiosity. Shall we delve deeper into three of the more common of these rare cannabinoids?

CBN: THC Transformed

Our first cannabinoid is CBN, which is a compound that arises when THC is subjected to high heat or light for long periods of time. This transformation is why cannabis with high levels of CBN has usually undergone oxidation or aging. It goes from being THC-9 (C21H30O2) to CBN (C21H26O2) by losing four Hydrogen molecules. 

But that sounds like a lot of confusing chemistry. What are the benefits of CBN and why should you care to know more about it? Before we continue to discuss the potential benefits and uses of CBN (in and out of the body), it needs to be understood that there is limited research on this compound. Only a handful of studies demonstrating CBN use in the human body have been published, and most current research focuses on its effects in mice (which, to these studies’ defense have remarkably similar nervous systems to humans. Who knew?)

The first use I want to focus on is the use of CBN as an antibacterial compound. In lab settings, CBN was tested on strains of MRSA bacteria that are resistant to traditional antibiotics. Researchers found it to be a potent antibacterial agent against these resistant strains. Perhaps in the future, we will see CBN used as a replacement for some antibiotic pairings. 

It may also have uses as a neuroprotectant. In one rodent study, researchers used CBN as a treatment for ALS and found that it was able to delay the onset of the condition. While further studies need to be conducted to determine if this effect is also seen in humans, these findings suggest that CBN may provide a powerful tool in the fight against ALS and other neurodegenerative conditions.

In other rodent studies, CBN increased the amount of food that rat subjects ate, suggesting that it could be an effective appetite stimulant. Since some avoid THC (another well-known appetite stimulant) due to its intoxicating effects, CBN could potentially offer an alternative for those seeking benefit without the high—but more research is needed.

Likely the most common recent application of this specific compound, however, has been to address those sleepless nights that I’m sure we are all too familiar with. CBN has long been associated with drowsiness. In the world of hemp and cannabis, there is a quote from Steep Hill, a cannabis laboratory, that is frequently used when describing CBN’s sedative effects. They claimed that the consumption of 2.5mgs to 5mgs pf CBN had the same level of sedation as a mild sedative, with a relaxed body sensation. More research is needed and Green Wellness does not diagnose, prescribe, or treat, but the potential sleep benefits are simply too good to ignore. With CBN sleep gummies, tinctures, and even capsules with higher levels of CBN, if interested there are lots of mechanisms to potentially benefit from the compound.

CBG: Decarboxylated CBGA

The CBG cannabinoid originally stems from CBGA. After undergoing an oxidation process, it becomes CBG, a compound that can directly interact with the endocannabinoid system of the body. 

One of the challenges of using CBG comes from the prohibitive cost of sourcing it. As a cannabis plant ages, more and more of the initial cannabinoids oxidize and turn into the common cannabinoids of CBD and THC. CBG, on the other hand, never comprises a significant proportion of the cannabinoids within a harvest of cannabis. 

This being said, despite the cost, difficulties of sourcing, and insufficient human research, CBG has been found to interact with the body’s CB1 and CB2 receptors, having a strong affinity for the CB2 receptor. These receptors regulate physiological processes such as mood, pain response, and appetite. More research is needed, however, as CBG appears to interact with the body’s endocannabinoid receptors differently than either THC or CBD, producing unique physiological effects.

While there’s an abundance of awareness around the major cannabinoids THC and CBD, less is known about CBG.  CBG shares some similarities with CBD: it seems to be anti-inflammatory and anti-bacterial. However, CBG also boasts its own unique set of properties, offering potential therapeutic benefits such as treatment for inflammatory bowel disease and glaucoma in animal tests. I know I’m a broken record here, but, more research is needed (especially in humans). 

CBDA: CBD’s Precursor 

I think it is fair to say that, if you are a regular customer of ours, you know quite a good deal about CBD. Even if you don’t take it regularly, it seems that CBD has entered into the public consciousness these days (with many misunderstandings abounding). But where does CBD come from? The easy answer is the cannabis plant, which is mainly true. But were you aware that there is a chemical precursor to CBD? That precursor is CBDA. 

So how does CBDA become CBD? With heat and time. Think of CBDA as the “raw” form of CBD. In fact, a lot of people will take CBDA in capsules, tinctures, and topicals to get that raw form into their daily diet. We’ve definitely got more options for CBDA than CBG or CBN. Green Wellness carries many CBDA products with brands like Endoca, Plus CBD, Entourage CBD, and Hemplucid. But what are the benefits of this?

Your CB1 and CB2 receptors are the primary nodes in your body for actively making use of CBD, both that which you take as a supplement and that which is naturally produced within your body. CBDA doesn’t work in this way. Instead, CBDA interacts with the endocannabinoid system by inhibiting the cyclooxygenase-2 (COX-2) enzyme. COX-2 enzymes are associated with inflammation after an injury or infection. By blocking COX-2 enzymes, CBDA can relieve inflammation and associated pain.

In one rodent study, scientists found CBDA affected levels of serotonin, a chemical produced by nerve cells to aid in signaling between cells. Serotonin is vital to core human functions like motor skills, sleeping, eating, digestion, and emotions. However, excess serotonin, which often is associated with stressors like chemotherapy, can cause nausea and vomiting. Vomiting can be controlled with medications, but nausea is harder to treat. But do not despair yet if you are a chemo patient! Scientists have demonstrated that CBDA can affect the body’s 5-HT serotonin-producing receptors, hinting at a potential use for CBDA as a medication for chemotherapy-induced nausea/vomiting (CINV) and other conditions that induce these symptoms. However, more research is needed.

We will keep you updated!

One recurrent theme throughout this blog was that more research was needed. While THC and CBD are gaining popularity, and the institutional barriers to research using these compounds are removed, it is important to keep in mind that there is a lot that is either not understood or is poorly understood about cannabis in relation to the human body. We will try to keep you up to date on relevant and recent research so that you can make informed decisions and purchases, and we always invite you to get in touch with us with any questions that you may have. 

As always, we hope that this was informative, and would love to hear from you on our social media accounts, our email, or on our phone lines. If you are ready to explore the world of CBD, give us a call at 888-772-7875, fill out an online contact form, or press the live chat button to speak with one of our experts.


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